Neurons convert synaptic or sensory inputs into cellular outputs. It is not well understood
how a single neuron senses, processes multiple stimuli, and generates distinct neuronal …

At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them
mechanically resistant to compressive forces. How this biochemical property of microtubule …

In Drosophila larvae, the class IV dendritic arborization (da) neurons are polymodal
nociceptors. Here, we show that ppk26 (CG8546) plays an important role in mechanical …

Here, we describe a targeted reverse genetic screen for thermal nociception genes in
Drosophila larvae. Using laser capture microdissection and microarray analyses of …

Insect olfactory receptors operate as ligand-gated ion channels that directly transduce odor
stimuli into electrical signals. However, in the absence of any known intermediate …

Insect pickpocket (PPK) receptors mediate diverse functions, among them the detection of
mechano-and chemo-sensory stimuli. Notwithstanding their relevance, studies on their …

Nutrition in early life has profound effects on an organism, altering processes such as
organogenesis. However, little is known about how specific nutrients affect neuronal …

Drosophila melanogaster larvae detect noxious thermal and mechanical stimuli in their
environment using polymodal nociceptor neurons whose dendrites tile the larval body wall …

Published assays for mechanical nociception in Drosophila have led to variable
assessments of behavior. Here, we fabricated, for use with Drosophila larvae, customized …

Somatosensory neurons (SSNs) that detect and transduce mechanical, thermal, and
chemical stimuli densely innervate an animal's skin. However, despite the fact that …