Activation of skeletal muscle fibers by somatic nerves results in vasodilation and functional
hyperemia. Sympathetic nerve activity is integral to vasoconstriction and the maintenance of …

The process of matching skeletal muscle blood flow to metabolism is complex and multi-
factorial. In response to exercise, increases in cardiac output, perfusion pressure and local …

Despite increases in muscle sympathetic vasoconstrictor activity, skeletal muscle blood flow
and O2 delivery increase during exercise in humans in proportion to the local metabolic …

Sympathetic vasoconstriction of muscle vascular beds is important in the regulation of
systemic blood pressure. However, vasoconstriction during exercise can also compromise …

We tested the hypothesis that nitric oxide (NO) is responsible for blunting sympathetic α‐
adrenergic vasoconstriction in the active muscles of humans (functional sympatholysis). We …

Skeletal muscle is one of the most dynamic metabolic organs as evidenced by increases in
metabolic rate of> 150-fold from rest to maximal contractile activity. Because of limited …

Recent evidence indicates that older healthy humans demonstrate greater vasoconstrictor
tone in their active muscles during exercise compared with young adults. Therefore, we …

Recent evidence suggests that adenosine triphosphate (ATP) can inhibit vasoconstrictor
responses to endogenous noradrenaline release via tyramine in the skeletal muscle …

Our previous work suggests that healthy human aging is associated with sex-specific
differences in leg vascular responses during large muscle mass exercise (2-legged …

Sex differences exist in autonomic control of the cardiovascular system. This study was
designed to directly test sex or female menstrual phase-related differences in α-adrenergic …