Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …

Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Single-cell nanopore sequencing of full-length mRNAs transforms single-cell multi-omics
studies. However, challenges include high sequencing errors and dependence on short …

RNA modifications have been historically considered as fine-tuning chemo-structural
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …

Abstract m6A is a prevalent internal modification in mRNAs and has been linked to the
diverse effects on mRNA fate. To explore the landscape and evolution of human m6A, we …

RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-
stranded RNA. This A-to-I editing occurs not only in protein-coding regions of mRNAs, but …

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …

In recent years, major breakthroughs in RNA-modification-mediated regulation of gene
expression have been made, leading to the emerging field of epitranscriptomics. Our …

Site-directed RNA editing might provide a safer or more effective alternative to genome
editing in certain clinical scenarios. Until now, RNA editing has relied on overexpression of …