The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

Characterizing the interactions that SARS-CoV-2 viral RNAs make with host cell proteins
during infection can improve our understanding of viral RNA functions and the host innate …

Myotonic Dystrophies type 1 (DM1) and type 2 (DM2) are complex multisystem diseases
without disease-based therapies. These disorders are caused by the expansions of unstable …

Abstract Background and Aims Survivors of acute coronary syndromes face an elevated risk
of recurrent atherosclerosis-related vascular events despite advanced medical treatments …

Guillain–Barré syndrome (GBS), an immune-mediated disorder affecting the peripheral
nervous system, is the most common and severe acute paralytic neuropathy. GBS remains …

The Coronavirus Disease 2019 (COVID-19) pandemic has become a global health
emergency with no effective medical treatment and with incipient vaccines. It is caused by a …

Aims The goal of our study was to investigate the heterogeneity of cardiac macrophages
(CMφs) in mice with transverse aortic constriction (TAC) via single-cell sequencing and …

Guanine-rich DNA strands can fold into non-canonical four-stranded secondary structures
named G-quadruplexes (G4). Experimental evidences suggest that G4-DNA surrounding …

The zinc finger CCHC-type (ZCCHC) superfamily proteins, characterized with the consensus
sequence C-X2-C-X4-H-X4-C, are accepted to have high-affinity binding to single-stranded …

Caspase-8 is a key integrator of cell survival and cell death decisions during infection and
inflammation. Following engagement of tumor necrosis factor superfamily receptors or …