The role of silicon in drug discovery: a review
JL Panayides, DL Riley, F Hasenmaile… - RSC Medicinal …, 2024 - pubs.rsc.org
This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …
often regarded as being similar with silicon located directly beneath carbon in the same …
Synthesis of bioactive spherical silver nanoparticles with surface plasmon resonance using ethanolic twig extract of Cratoxylum formosum ssp. pruniflorum
K Kaimuangpak, K Tamprasit, A Date… - Journal of Drug Delivery …, 2023 - Elsevier
Silver nanoparticles (AgNPs) are remarkable nanoparticles among other metal
nanoparticles due to their relatively more cost-effective production, smaller size, and more …
nanoparticles due to their relatively more cost-effective production, smaller size, and more …
Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database
C Herrera-Acevedo, C Perdomo-Madrigal… - Molecular Diversity, 2021 - Springer
Alzheimer's disease is the most common form of dementia, representing 60–70% of
dementia cases. The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in …
dementia cases. The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in …
In Silico Studies of Lamiaceae Diterpenes with Bioinsecticide Potential against Aphis gossypii and Drosophila melanogaster
GCS Rodrigues, M dos Santos Maia… - Molecules, 2021 - mdpi.com
Background: The growing demand for agricultural products has led to the misuse/overuse of
insecticides; resulting in the use of higher concentrations and the need for ever more toxic …
insecticides; resulting in the use of higher concentrations and the need for ever more toxic …
Silicon containing ibuprofen derivatives with antioxidant and anti-inflammatory activities: An in vivo and in silico study
DJ Pérez, MI Díaz-Reval, F Obledo-Benicio… - European journal of …, 2017 - Elsevier
There are many chronic diseases related with inflammation. The chronic inflammation can
produce other problems as cancer. Therefore, it is necessary to design drugs with better anti …
produce other problems as cancer. Therefore, it is necessary to design drugs with better anti …
One-pot preparation of polylactic acid-ibuprofen conjugates and their performance characterization
SH Luo, YC Wu, L Cao, QF Wang, SX Chen… - Polymer …, 2017 - pubs.rsc.org
A series of polylactic acid-ibuprofen (PLA-IBU) conjugates was directly synthesized via melt
polycondensation of lactic acid (LA) with ibuprofen (IBU) in the presence of 0.3 wt% SnO at …
polycondensation of lactic acid (LA) with ibuprofen (IBU) in the presence of 0.3 wt% SnO at …
In silico structure‐based design of GABAB receptor agonists using a combination of docking and QSAR
Z Martínez‐Campos, N Pastor… - Chemical Biology & …, 2019 - Wiley Online Library
The study of γ‐aminobutyric acid B receptor (GABAB) activation is of great interest for
several brain disorders. The search of new GABAB receptor agonists has been carried out …
several brain disorders. The search of new GABAB receptor agonists has been carried out …
Discovery of Octahydroisoindolone as a Scaffold for the Selective Inhibition of Chitinase B1 from Aspergillus fumigatus: In Silico Drug Design Studies
A Marbán-González, A Hernández-Mendoza… - Molecules, 2021 - mdpi.com
Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis
since they are necessary for fungal cell wall remodeling. This study presents the design of …
since they are necessary for fungal cell wall remodeling. This study presents the design of …
Synthetic Strategies Towards Safer NSAIDs Through Prodrug Approach: A Review
Non-steroidal anti-inflammatory drugs (NSAIDs) are agents that are used for various
properties such as analgesic activity, anti-inflammatory activity, antipyretic activity, etc. But …
properties such as analgesic activity, anti-inflammatory activity, antipyretic activity, etc. But …
[PDF][PDF] 基于布洛芬的结构修饰研究进展
罗潇， 朱玉超， 霍童雨， 焦宁 - 中国医药工业杂志, 2018 - cjph.com.cn
布洛芬是临床上广泛应用的一种非甾体抗炎药, 有超过50 年的使用历史. 近年来基于布洛芬的
结构修饰仍在进行, 以求获得活性更高的化合物或解决其存在的不良反应. 本文从对布洛芬进行 …
结构修饰仍在进行, 以求获得活性更高的化合物或解决其存在的不良反应. 本文从对布洛芬进行 …