Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …

Biosensors have been employed for monitoring and imaging biological events and
molecules. Sensitive detection of different biomolecules in vivo can reflect the changes of …

The development of RNA aptamers/fluorophores system is highly desirable for
understanding the dynamic molecular biology of RNAs in vivo. Peppers-based imaging …

Protein-based fluorescent reporters have been widely used to characterize and localize
biological processes in living cells. However, these reporters may have certain drawbacks …

Single-nucleotide variation (SNV) imaging can indicate cellular heterogeneity and spatial
pattern, but it remains challenging to produce high-gain signal while also yielding single …

Aptamers are oligonucleotide-based affinity reagents that are increasingly being used in
various applications. Systematic evolution of ligands by exponential enrichment (SELEX) …

Nucleic acids are not only essential actors of cell life but also extremely appealing molecular
objects in the development of synthetic molecules for biotechnological application, such as …

Since aptamers were discovered for about 30 years, they have already great capacity for
potential applications, like biosensor construction and bioanalysis. However, for more …

Lumpy skin disease virus (LSDV) is a severe and highly contagious form of cowpox. As
LSDV continues to mutate and there is no vaccine and treatment in nonendemic countries …

We herein describe a new multicolor fluorogenic RNA aptasensor to accomplish multiplexed
detection of miRNAs. The stem-loop primer (SL primer) entailing a fluorogenic RNA aptamer …