Redox systems biology: harnessing the sentinels of the cysteine redoxome
JM Held - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Cellular redox processes are highly interconnected, yet not in equilibrium, and
governed by a wide range of biochemical parameters. Technological advances continue …
governed by a wide range of biochemical parameters. Technological advances continue …
Oxygen response and tolerance mechanisms in Clostridioides difficile
N Kint, C Morvan, I Martin-Verstraete - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Low oxygen tensions are present throughout the gastrointestinal tract.•Although
Clostridioides difficile is considered as obligate anaerobe, this bacterium can tolerate low …
Clostridioides difficile is considered as obligate anaerobe, this bacterium can tolerate low …
Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination
T Nietzel, J Mostertz, C Ruberti, G Née… - Proceedings of the …, 2020 - National Acad Sciences
Seeds preserve a far developed plant embryo in a quiescent state. Seed metabolism relies
on stored resources and is reactivated to drive germination when the external conditions are …
on stored resources and is reactivated to drive germination when the external conditions are …
Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation
JB Behring, S van der Post, AD Mooradian, MJ Egan… - Science …, 2020 - science.org
Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal
growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species …
growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species …
Redox proteomes in human physiology and disease mechanisms
A Mannaa, FG Hanisch - Journal of proteome research, 2019 - ACS Publications
Redox proteomics is a field of proteomics that is concerned with the characterization of the
oxidation state of proteins to gain information about their modulated structure, function …
oxidation state of proteins to gain information about their modulated structure, function …
Ebselen not only inhibits Clostridioides difficile toxins but displays redox-associated cellular killing
Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB
by covalently binding to their cysteine protease domains. It was suggested that ebselen …
by covalently binding to their cysteine protease domains. It was suggested that ebselen …
Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile
NG Metzendorf, LM Lange, N Lainer… - Frontiers in …, 2022 - frontiersin.org
The anaerobic bacterium Clostridioides difficile represents one of the most problematic
pathogens, especially in hospitals. Dysbiosis has been proven to largely reduce …
pathogens, especially in hospitals. Dysbiosis has been proven to largely reduce …
Nucleoredoxin‐Dependent Targets and Processes in Neuronal Cells
C Urbainsky, R Nölker, M Imber… - Oxidative medicine …, 2018 - Wiley Online Library
Nucleoredoxin (Nrx) is an oxidoreductase of the thioredoxin family of proteins. It was shown
to act as a signal transducer in some pathways; however, so far, no comprehensive analysis …
to act as a signal transducer in some pathways; however, so far, no comprehensive analysis …
Diamide-based screening method for the isolation of improved oxidative stress tolerance phenotypes in Bacillus mutant libraries
J Walgraeve, B Ferrero-Bordera, S Maaß… - Microbiology …, 2023 - Am Soc Microbiol
The bacterium Bacillus subtilis is of high importance both as a model organism for Gram-
positive bacteria and as an industrial workhorse in the production of biomolecules. In recent …
positive bacteria and as an industrial workhorse in the production of biomolecules. In recent …
Differential View on the Bile Acid Stress Response of Clostridioides difficile
S Sievers, NG Metzendorf, S Dittmann… - Frontiers in …, 2019 - frontiersin.org
Clostridioides difficile is an intestinal human pathogen that uses the opportunity of a
depleted microbiota to cause an infection. It is known, that the composition of the intestinal …
depleted microbiota to cause an infection. It is known, that the composition of the intestinal …