Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Multicellular organisms are constantly subjected to pathogens that might be harmful.
Although insects lack an adaptive immune system, they possess highly effective anti …

Integrating human genomics and proteomics can help elucidate disease mechanisms,
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …

Background The risk of second tumors after chimeric antigen receptor (CAR) T-cell therapy,
especially the risk of T-cell neoplasms related to viral vector integration, is an emerging …

Tumours most often arise from progression of precursor clones within a single anatomical
niche. In the bone marrow, clonal progenitors can undergo malignant transformation to …

Epigenetic reinforcement of T cell exhaustion is known to be a major barrier limiting T cell
responses during immunotherapy. However, the core epigenetic regulators restricting …

More than a decade ago IL-1 blockade was suggested as an add-on therapy for the
treatment of cancer. This proposal was based on the overall safety record of anti-IL-1 …

The recognition of host genetic factors underlying susceptibility to hematopoietic
malignancies has increased greatly over the last decade. Historically, germline …

Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …

Inflammasomes are multimeric protein complexes, sensors of intracellular danger signals,
and crucial components of the innate immune system, with the NLRP3 inflammasome being …