Functional biomaterials for osteoarthritis treatment: from research to application

Y Lei, Q Zhang, G Kuang, X Wang, Q Fan… - Smart Medicine, 2022 - Wiley Online Library
Osteoarthritis (OA) is a common disease that endangers millions of middle‐aged and elderly
people worldwide. Researchers from different fields have made great efforts and achieved …

Knee osteoarthritis therapy: recent advances in intra-articular drug delivery systems

L Ma, X Zheng, R Lin, ARJ Sun, J Song… - Drug design …, 2023 - Taylor & Francis
Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …

[HTML][HTML] Kinematic alignment versus mechanical alignment in primary total knee arthroplasty: an updated meta-analysis of randomized controlled trials

B Liu, C Feng, C Tu - Journal of Orthopaedic Surgery and Research, 2022 - Springer
Background The purpose of this study was to perform an updated meta-analysis to compare
the outcomes of kinematic alignment (KA) and mechanical alignment (MA) in patients …

Targeting regulated chondrocyte death in osteoarthritis therapy

R Zhu, Y Wang, Z Ouyang, W Hao, F Zhou, Y Lin… - Biochemical …, 2023 - Elsevier
In vivo articular cartilage degeneration is an essential hallmark of osteoarthritis (OA),
involving chondrocyte senescence, extracellular matrix degradation, chondrocyte death …

Biodegradable piezoelectric skin-wound scaffold

R Das, TT Le, B Schiff, MT Chorsi, J Park, P Lam… - Biomaterials, 2023 - Elsevier
Electrical stimulation (ES) induces wound healing and skin regeneration. Combining ES
with the tissue-engineering approach, which relies on biomaterials to construct a …

Dual-switched carbon monoxide nano gas tank for auto-diagnosis and precision therapy of osteoarthritis

X Gao, L Yan, W Zhang, Y Lv, P Ou, R Hang, A Gao… - Nano Today, 2023 - Elsevier
Carbon monoxide (CO) has great potential in the therapy of osteoarthritis (OA), but its
controllable delivery in vivo is still an intractable problem. To optimize CO gas therapy for …

[HTML][HTML] Therapeutic perspectives for inflammation and senescence in osteoarthritis using mesenchymal stem cells, mesenchymal stem cell-derived extracellular …

MG Rizzo, TM Best, J Huard, M Philippon, F Hornicek… - Cells, 2023 - mdpi.com
Osteoarthritis (OA) is the most common cause of disability worldwide among the elderly.
Alarmingly, the incidence of OA in individuals less than 40 years of age is rising, likely due to …

[HTML][HTML] Exosomes from osteoarthritic fibroblast-like synoviocytes promote cartilage ferroptosis and damage via delivering microRNA-19b-3p to target SLC7A11 in …

R Kong, L Ji, Y Pang, D Zhao, J Gao - Frontiers in Immunology, 2023 - frontiersin.org
Objective Our previous studies revealed that normal synovial exosomes promoted
chondrogenesis, and microRNA (miR)-19b-3p independently related to osteoarthritis (OA) …

[HTML][HTML] New viscoelastic hydrogel hymovis MO. RE. Single intra-articular injection for the treatment of knee osteoarthritis in sportsmen: safety and efficacy study …

A Bernetti, F Agostini, F Alviti, N Giordan… - Frontiers in …, 2021 - frontiersin.org
Viscosupplementation by hyaluronic acid (HA) is recommended for non-surgical
management of knee osteoarthritis (OA). This study investigated the efficacy and safety of a …

Patient-related barriers and enablers to the implementation of high-value physiotherapy for chronic pain: a systematic review

C Dickson, RMJ de Zoete, C Berryman… - Pain …, 2024 - academic.oup.com
Objective To identify and synthesize patient-related barriers to and enablers of the
implementation of high-value physiotherapy (HVP) for chronic pain. Furthermore, to review …