Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

The development of nanovaccines that employ polymeric delivery carriers has garnered
substantial interest in therapeutic treatment of cancer and a variety of infectious diseases …

Intravenous injection of a variety of nanotechnology enhanced (liposomal, micellar, polymer-
conjugated) and protein-based (antibodies, enzymes) drugs can lead to hypersensitivity …

Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

Triple-negative breast cancer (TNBC) is an aggressive disease with a short median time
from relapse to death. The increased aggressiveness, drug resistance, disease relapse, and …

Small interfering RNAs (siRNAs) are among the most promising therapeutic platforms in
many life-threatening diseases. Owing to the significant advances in siRNA design, many …

Preclinical characterization of novel nanotechnology-based formulations is often challenged
by physicochemical characteristics, sterility/sterilization issues, safety and efficacy. Such …

Polyethylenimine (PEI) is a gold standard polycationic transfectant. However, the highly
efficient transfecting activity of PEI and many of its derivatives is accompanied by serious …

The current medical reality of cancer gene therapy is reflected by more than ten approved
products on the global market, including oncolytic and other viral vectors and CAR T-cells as …

Inhaled gene carriers must penetrate the highly viscoelastic and adhesive mucus barrier in
the airway in order to overcome rapid mucociliary clearance and reach the underlying …