Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
Histamine and scombrotoxins
JM Hungerford - Toxicon, 2021 - Elsevier
Histamine intoxications result when histamine-metabolizing enzymes are compromised or
overwhelmed by dietary histamine in the human body. This can occur either due to …
overwhelmed by dietary histamine in the human body. This can occur either due to …
Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics
D Yadav, P Kumar - Neurochemistry international, 2022 - Elsevier
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
Histamine, neuroinflammation and neurodevelopment: a review
E Carthy, T Ellender - Frontiers in neuroscience, 2021 - frontiersin.org
The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …
processes as well as the properties of neurons and synapses in the brain, and is also …
Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson's disease
B Cao, Y Zhang, J Chen, P Wu, Y Dong, Y Wang - Metabolic brain disease, 2022 - Springer
Parkinson's disease (PD) is a neurodegenerative disease with increasing incidence in aged
populations, second only to Alzheimer's disease. Increasing evidence has shown that …
populations, second only to Alzheimer's disease. Increasing evidence has shown that …
Towards improved screening of toxins for Parkinson's risk
Parkinson's disease (PD) is a chronic, progressive and disabling neurodegenerative
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
Literature-based discovery predicts antihistamines are a promising repurposed adjuvant therapy for Parkinson's disease
G Tandra, A Yoone, R Mathew, M Wang… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is a movement disorder caused by a dopamine deficit in the brain.
Current therapies primarily focus on dopamine modulators or replacements, such as …
Current therapies primarily focus on dopamine modulators or replacements, such as …
[HTML][HTML] Drug repurposing: Clemastine fumarate and neurodegeneration
J Zhu, R Ma, G Li - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Neurodegenerative diseases have been a weighty problem in elder people who might be
stricken with motor or/and cognition defects with lower life quality urging for effective …
stricken with motor or/and cognition defects with lower life quality urging for effective …
[HTML][HTML] TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis
P Ye, Q Fang, X Hu, W Zou, M Huang, M Ke, Y Li… - Progress in …, 2023 - Elsevier
Different dopaminergic (DA) neuronal subgroups exhibit distinct vulnerability to stress, while
the underlying mechanisms are elusive. Here we report that the transient receptor potential …
the underlying mechanisms are elusive. Here we report that the transient receptor potential …
Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti …
A Sharma, DF Muresanu, R Patnaik, PK Menon… - Progress in Brain …, 2021 - Elsevier
Military personnel deployed in combat operations are highly prone to develop Parkinson's
disease (PD) in later lives. PD largely involves dopaminergic pathways with hallmarks of …
disease (PD) in later lives. PD largely involves dopaminergic pathways with hallmarks of …