Prions are unprecedented infectious pathogens that cause a group of invariably fatal
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …

The human prion diseases are fatal neurodegenerative maladies that may present as
sporadic, genetic, or infectious illnesses. The sporadic form is called Creutzfeldt‐Jakob …

Variations in prions, which cause different incubation times and deposition patterns of the
prion protein isoform called PrP Sc, are often referred to as' strains'. We report here a highly …

Prion diseases are fatal neurodegenerative disorders in man and animal associated with
conformational conversion of a cellular prion protein (PrPc) into the pathologic isoform …

There is growing concern that bovine spongiform encephalopathy (BSE) may have passed
from cattle to humans. We report here that transgenic (Tg) mice expressing bovine (Bo) prion …

Electroecenphalography (EEG) is an integral part of the diagnostic process in patients with
Creutzfeldt–Jakob disease (CJD). The EEG has therefore been included in the World Health …

Formation of aberrant protein conformers is a common pathological denominator of different
neurodegenerative disorders, such as Alzheimer's disease or prion diseases. Moreover …

There is little doubt that the main component of the transmissible agent of spongiform
encephalopathies—the prion—is a conformational variant of the ubiquitous host protein …

▪ Abstract The prion hypothesis proposes that proteins can act as infectious agents.
Originally formulated to explain transmissible spongiform encephalopathies (TSEs), the …

Transmissible spongiform encephalopathies (TSEs) or prion diseases of animals notably
include scrapie in small ruminants, chronic wasting disease (CWD) in cervids and classical …