Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …

To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-
associated receptors and factors (SCARFs) using single-cell transcriptomics across various …

Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …

Profound global loss of DNA methylation is a hallmark of many cancers. One potential
consequence of this is the reactivation of transposable elements (TEs) which could stimulate …

Pathways underlying mouse embryonic development have always informed efforts to derive,
maintain, and drive differentiation of human pluripotent stem cells. However, direct …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …

The study of de novo protein-coding genes is maturing from the ad hoc reporting of
individual cases to the systematic analysis of extensive genomic data from several species …

Highlights•Endogenous viral elements (EVEs) account for a substantial fraction (∼ 10%) of
mammalian genomes.•EVEs represent an abundant source of coding and noncoding …