New insights into acute pancreatitis

PJ Lee, GI Papachristou - Nature reviews Gastroenterology & …, 2019 - nature.com
The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Organ failure due to systemic injury in acute pancreatitis

PK Garg, VP Singh - Gastroenterology, 2019 - Elsevier
Acute pancreatitis may be associated with both local and systemic complications. Systemic
injury manifests in the form of organ failure, which is seen in approximately 20% of all cases …

Olezarsen, acute pancreatitis, and familial chylomicronemia syndrome

ESG Stroes, VJ Alexander… - … England Journal of …, 2024 - Mass Medical Soc
Background Familial chylomicronemia syndrome is a genetic disorder associated with
severe hypertriglyceridemia and severe acute pancreatitis. Olezarsen reduces the plasma …

Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase …

I Gouni-Berthold, VJ Alexander, Q Yang… - The lancet Diabetes & …, 2021 - thelancet.com
Background Volanesorsen is an antisense oligonucleotide that targets hepatic
apolipoprotein C-III synthesis and reduces plasma triglyceride concentration. The aim of this …

A modern approach to dyslipidemia

AJ Berberich, RA Hegele - Endocrine reviews, 2022 - academic.oup.com
Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are
commonly encountered in clinical practice and often have implications for cardiovascular …

Hypertriglyceridemia and acute pancreatitis

AL Yang, J McNabb-Baltar - Pancreatology, 2020 - Elsevier
Hypertriglyceridemia is the third most common cause of acute pancreatitis. It typically occurs
in patients with an underlying disorder of lipoprotein metabolism and in the presence of a …

Management of hypertriglyceridemia induced acute pancreatitis

R Garg, T Rustagi - BioMed research international, 2018 - Wiley Online Library
Hypertriglyceridemia is an uncommon but a well‐established etiology of acute pancreatitis
leading to significant morbidity and mortality. The risk and severity of acute pancreatitis …

Acute pancreatitis: a multifaceted set of organelle and cellular interactions

A Habtezion, AS Gukovskaya, SJ Pandol - Gastroenterology, 2019 - Elsevier
Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

Management of severe acute pancreatitis

OJ Hines, SJ Pandol - Bmj, 2019 - bmj.com
The risks, measurements of severity, and management of severe acute pancreatitis and its
complications have evolved rapidly over the past decade. Evidence suggests that initial goal …

Obesity and pancreatitis

B Khatua, B El-Kurdi, VP Singh - Current opinion in …, 2017 - journals.lww.com
We discuss how obesity may contribute to increasing acute pancreatitis incidence, the role
of lipolytic unsaturated fatty acid release in worsening acute pancreatitis, and potential …