Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-
reperfusion injury in the heart and several degenerative diseases, including muscular …

The mitochondrial permeability transition pore (mPTP) is a channel in the inner
mitochondrial membrane whose sustained opening in response to elevated mitochondrial …

Abstract The mitochondrial Permeability Transition Pore (PTP) can be defined as a Ca 2+
activated mega-channel involved in mitochondrial damage and cell death, making its …

Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major
contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is …

At least seven cell death programs are activated during myocardial infarction (MI), but which
are most important in causing heart damage is not understood. Two of these programs are …

Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including
the production of reactive oxygen species (ROS), altered cellular osmolarity, and …

Coronary artery disease has one of the highest mortality rates in the country, and methods
such as thrombolysis and percutaneous coronary intervention (PCI) can effectively improve …

Modulation of mitochondrial K channels represents a pharmacological strategy to promote
cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing …