Adaptable hydrogel networks with reversible linkages for tissue engineering
H Wang, SC Heilshorn - Advanced Materials, 2015 - Wiley Online Library
Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …
AKAP signalling complexes: focal points in space and time
Multiprotein signalling networks create focal points of enzyme activity that disseminate the
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a …
high mortality, uncertain cause, and few treatment options. Studies have identified a …
Localized effects of cAMP mediated by distinct routes of protein kinase A
K Taskén, EM Aandahl - Physiological reviews, 2004 - journals.physiology.org
Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …
[HTML][HTML] The many faces of compartmentalized PKA signalosomes
O Torres-Quesada, JE Mayrhofer, E Stefan - Cellular signalling, 2017 - Elsevier
Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …
molecular interactions. At the cell surface information is received by receptor complexes and …
AKAP signaling islands: venues for precision pharmacology
Regulatory enzymes often have different roles in distinct subcellular compartments. Yet,
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …
Molecular mechanisms for cAMP-mediated immunoregulation in T cells–role of anchored protein kinase a signaling units
VL Wehbi, K Taskén - Frontiers in immunology, 2016 - frontiersin.org
The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and
versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target …
versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target …
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization
J Jin, FD Smith, C Stark, CD Wells, JP Fawcett… - Current biology, 2004 - cell.com
Abstract Background: 14-3-3 proteins are abundant and conserved polypeptides that
mediate the cellular effects of basophilic protein kinases through their ability to bind specific …
mediate the cellular effects of basophilic protein kinases through their ability to bind specific …
Protein kinase C pharmacology: refining the toolbox
AX Wu-Zhang, AC Newton - Biochemical Journal, 2013 - portlandpress.com
PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …
[HTML][HTML] Molecular basis of AKAP specificity for PKA regulatory subunits
Localization of cyclic AMP (cAMP)-dependent protein kinase (PKA) by A kinase-anchoring
proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution …
proteins (AKAPs) restricts the action of this broad specificity kinase. The high-resolution …