The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy
Z Iqbal, S Azmi, R Yadav, M Ferdousi, M Kumar… - Clinical …, 2018 - Elsevier
Purpose Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy
worldwide, and its prevalence increases with the duration of diabetes. It affects …
worldwide, and its prevalence increases with the duration of diabetes. It affects …
In vivo confocal microscopy of corneal nerves in health and disease
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …
Corneal nerves in health and disease
BS Shaheen, M Bakir, S Jain - Survey of ophthalmology, 2014 - Elsevier
Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …
an important role in the blink reflex, wound healing, and tear production and secretion …
Emerging biomarkers, tools, and treatments for diabetic polyneuropathy
GJ Bönhof, C Herder, A Strom, N Papanas… - Endocrine …, 2019 - academic.oup.com
Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …
Corneal confocal microscopy identifies corneal nerve fibre loss and increased dendritic cells in patients with long COVID
G Bitirgen, C Korkmaz, A Zamani… - British Journal of …, 2022 - bjo.bmj.com
Background/Aims Long COVID is characterised by a range of potentially debilitating
symptoms which develop in at least 10% of people who have recovered from acute SARS …
symptoms which develop in at least 10% of people who have recovered from acute SARS …
Neurotrophic keratitis: current challenges and future prospects
P Versura, G Giannaccare, M Pellegrini… - Eye and …, 2018 - Taylor & Francis
Neurotrophic keratitis (NK) is a degenerative corneal disease caused by damage of
trigeminal corneal innervation, which leads to spontaneous epithelial breakdown and …
trigeminal corneal innervation, which leads to spontaneous epithelial breakdown and …
Diagnosis of neuropathy and risk factors for corneal nerve loss in type 1 and type 2 diabetes: a corneal confocal microscopy study
M Ferdousi, A Kalteniece, S Azmi… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE To assess the diagnostic utility of corneal confocal microscopy (CCM) for
diabetic peripheral neuropathy (DPN) and the risk factors for corneal nerve loss …
diabetic peripheral neuropathy (DPN) and the risk factors for corneal nerve loss …
Early detection of diabetic peripheral neuropathy: a focus on small nerve fibres
J Burgess, B Frank, A Marshall, RS Khalil, G Ponirakis… - Diagnostics, 2021 - mdpi.com
Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2
diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations …
diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations …
Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy
OBJECTIVE The accurate quantification of human diabetic neuropathy is important to define
at-risk patients, anticipate deterioration, and assess new therapies. RESEARCH DESIGN …
at-risk patients, anticipate deterioration, and assess new therapies. RESEARCH DESIGN …