Reductive amination in the synthesis of pharmaceuticals
OI Afanasyev, E Kuchuk, DL Usanov… - Chemical reviews, 2019 - ACS Publications
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry
owing to its synthetic merits and the ubiquitous presence of amines among biologically …
owing to its synthetic merits and the ubiquitous presence of amines among biologically …
Lithiation–borylation methodology and its application in synthesis
D Leonori, VK Aggarwal - Accounts of chemical research, 2014 - ACS Publications
Conspectus Developing new methods that enable the synthesis of new and complex
molecules with complete control of their 3-D shape is central to the advancement of synthetic …
molecules with complete control of their 3-D shape is central to the advancement of synthetic …
[HTML][HTML] Stereospecific functionalizations and transformations of secondary and tertiary boronic esters
C Sandford, VK Aggarwal - Chemical Communications, 2017 - pubs.rsc.org
The formation of highly enantioenriched boronic esters through both stoichiometric and
catalytic methods has received much attention over the past decade. Accordingly, the …
catalytic methods has received much attention over the past decade. Accordingly, the …
Copper‐Catalyzed Enantioselective 1,6‐Boration of para‐Quinone Methides and Efficient Transformation of gem‐Diarylmethine Boronates to Triarylmethanes
Y Lou, P Cao, T Jia, Y Zhang, M Wang… - Angewandte …, 2015 - Wiley Online Library
Presented is the first enantioselective copper‐catalyzed 1, 6‐conjugate addition of bis
(pinacolato) diboron to para‐quinone methides. The reaction proceeds with excellent yields …
(pinacolato) diboron to para‐quinone methides. The reaction proceeds with excellent yields …
A catalytic enantiotopic-group-selective Suzuki reaction for the construction of chiral organoboronates
C Sun, B Potter, JP Morken - Journal of the American Chemical …, 2014 - ACS Publications
Catalytic enantiotopic-group-selective cross-couplings of achiral geminal bis
(pinacolboronates) provide a route for the construction of nonracemic chiral …
(pinacolboronates) provide a route for the construction of nonracemic chiral …
Synthesis of hydroxyphthioceranic acid using a traceless lithiation–borylation–protodeboronation strategy
R Rasappan, VK Aggarwal - Nature Chemistry, 2014 - nature.com
In planning organic syntheses, disconnections are most often made adjacent to functional
groups, which assist in C–C bond formation. For molecules devoid of obvious functional …
groups, which assist in C–C bond formation. For molecules devoid of obvious functional …
Overview on the recent strategies for the enantioselective synthesis of 1, 1‐diarylalkanes, triarylmethanes and related molecules containing the diarylmethine …
There has recently been an increased interest in active pharmaceutical agents and various
other molecules that contain the 1, 1‐diaryl stereocenter. This has led to the development of …
other molecules that contain the 1, 1‐diaryl stereocenter. This has led to the development of …
The Matteson Reaction
DS Matteson, BSL Collins, VK Aggarwal… - Organic …, 2004 - Wiley Online Library
The Matteson reaction is the nucleophilic displacement of a leaving group from the α‐carbon
of an alkylboronic ester. The reaction proceeds through an (α‐haloalkyl) boronate complex …
of an alkylboronic ester. The reaction proceeds through an (α‐haloalkyl) boronate complex …
[HTML][HTML] Chiral Fe (II) complex catalyzed enantioselective [1, 3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
L Wang, P Zhou, Q Lin, S Dong, X Liu, X Feng - Chemical Science, 2020 - pubs.rsc.org
A highly efficient enantioselective [1, 3] O-to-C rearrangement of racemic vinyl ethers that
operates under mild conditions was developed. This method with chiral ferrous complex …
operates under mild conditions was developed. This method with chiral ferrous complex …
A complementary toolbox of iterative methods for the stereoselective synthesis of heteroatom-rich motives from C1-building blocks
S Kirupakaran, HG Korth, C Hirschhäuser - Synthesis, 2018 - thieme-connect.com
The ability to assemble organic molecules one carbon atom at a time has been a long-held
dream for chemists. Modern boronate homologations with chiral carbenoids allow for the …
dream for chemists. Modern boronate homologations with chiral carbenoids allow for the …