Mechanics and functional consequences of nuclear deformations
As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …
fate and function in response to various signals and stimuli. In addition to biochemical …
Nuclear size and shape control
H Cantwell, G Dey - Seminars in Cell & Developmental Biology, 2022 - Elsevier
The nucleus displays a wide range of sizes and shapes in different species and cell types,
yet its size scaling and many of the key structural constituents that determine its shape are …
yet its size scaling and many of the key structural constituents that determine its shape are …
Brillouin light scattering anisotropy microscopy for imaging the viscoelastic anisotropy in living cells
H Keshmiri, D Cikes, M Samalova, L Schindler… - Nature …, 2024 - nature.com
Maintaining and modulating mechanical anisotropy is essential for biological processes.
However, how this is achieved at the microscopic scale in living soft matter is not always …
However, how this is achieved at the microscopic scale in living soft matter is not always …
Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus
The large-scale organization of the genome inside the cell nucleus is critical for the cell's
function. Chromatin—the functional form of DNA in cells—serves as a template for active …
function. Chromatin—the functional form of DNA in cells—serves as a template for active …
Interphase chromatin undergoes a local sol-gel transition upon cell differentiation
Cell differentiation, the process by which stem cells become specialized cells, is associated
with chromatin reorganization inside the cell nucleus. Here, we measure the chromatin …
with chromatin reorganization inside the cell nucleus. Here, we measure the chromatin …
HP1-driven phase separation recapitulates the thermodynamics and kinetics of heterochromatin condensate formation
MMC Tortora, LD Brennan… - Proceedings of the …, 2023 - National Acad Sciences
The spatial segregation of pericentromeric heterochromatin (PCH) into distinct, membrane-
less nuclear compartments involves the binding of Heterochromatin Protein 1 (HP1) to …
less nuclear compartments involves the binding of Heterochromatin Protein 1 (HP1) to …
Activity-driven phase transition causes coherent flows of chromatin
We discover a new type of nonequilibrium phase transition in a model of chromatin
dynamics, which accounts for the coherent motions that have been observed in experiment …
dynamics, which accounts for the coherent motions that have been observed in experiment …
Probe-free optical chromatin deformation and measurement of differential mechanical properties in the nucleus
The nucleus is highly organized to facilitate coordinated gene transcription. Measuring the
rheological properties of the nucleus and its sub-compartments will be crucial to understand …
rheological properties of the nucleus and its sub-compartments will be crucial to understand …
Conformations, correlations, and instabilities of a flexible fiber in an active fluid
Fluid-structure interactions between active and passive components are important for many
biological systems to function. A particular example is chromatin in the cell nucleus, where …
biological systems to function. A particular example is chromatin in the cell nucleus, where …
A liquid state perspective on dynamics of chromatin compartments
The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …