Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …

Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …

Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

The brain is composed of many lipids with varied forms that serve not only as structural
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …

For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce
demyelination, without a clear understanding of its mechanisms. LPC is an endogenous …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …

Lysophosphatidic acid (LPA, 1-or 2-acyl-sn-glycerol 3-phosphate) is a simple phospholipid
but displays an intriguing cell biology that is mediated via interactions with G protein …

Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …