Opioid drugs are important tools to alleviate pain of different origins, but they have strong
addictive potential and their abuse at higher doses often results in serious health …

Opioid use disorder (OUD) has gained increasing publicity and interest during recent years,
with many countries describing problems of epidemic proportions with regard to opioid use …

Drug-evoked adaptations in the mesolimbic dopamine system are postulated to drive opioid
abuse and addiction. These adaptations vary in magnitude and direction following different …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Heroin rapidly enters the CNS but is quickly metabolized into 6-monoacetylmorphine (6-
MAM) and then morphine. Although morphine is often thought to mediate heroin's neural …

The opioid health crisis is a complex and multifaceted public health emergency that has 34
been unfolding across the globe, with particularly devastating impacts in the United States. It …

Introduction/objectives Many individuals with rheumatoid arthritis (RA) report persistent
fatigue even after management of peripheral disease activity. This study used whole-brain …

Drug efficacy can be improved by understanding the effects of anesthesia on the
neurovascular system. In this study, we used machine learning algorithms to predict the risk …

Background: Drug-evoked adaptations in the mesolimbic dopamine system drive opioid
abuse and addiction, but these adaptations vary in magnitude and direction following …