Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression
Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study
VR Varma, AM Oommen, S Varma, R Casanova… - PLoS …, 2018 - journals.plos.org
Background The metabolic basis of Alzheimer disease (AD) is poorly understood, and the
relationships between systemic abnormalities in metabolism and AD pathogenesis are …
relationships between systemic abnormalities in metabolism and AD pathogenesis are …
Metabolic network failures in Alzheimer's disease: A biochemical road map
Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015
incorporated experts from academia, industry, and nonprofit organizations to develop new …
incorporated experts from academia, industry, and nonprofit organizations to develop new …
Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study
SG Snowden, AA Ebshiana, A Hye, Y An… - PLoS …, 2017 - journals.plos.org
Background The metabolic basis of Alzheimer disease (AD) pathology and expression of AD
symptoms is poorly understood. Omega-3 and-6 fatty acids have previously been linked to …
symptoms is poorly understood. Omega-3 and-6 fatty acids have previously been linked to …
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
In advanced age, some individuals maintain a stable cognitive trajectory while others
experience a rapid decline. Such variation in cognitive trajectory is only partially explained …
experience a rapid decline. Such variation in cognitive trajectory is only partially explained …
Blood-based biomarkers for Alzheimer's disease diagnosis and progression: an overview
A Varesi, A Carrara, VG Pires, V Floris, E Pierella… - Cells, 2022 - mdpi.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …
Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers
The brain is highly enriched in lipids, and an intensive study of these lipids may be
informative, not only of normal brain function but also of changes with age and in disease. In …
informative, not only of normal brain function but also of changes with age and in disease. In …
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
Background Alzheimer's disease (AD) is associated with metabolic abnormalities linked to
critical elements of neurodegeneration. We recently administered combined metabolic …
critical elements of neurodegeneration. We recently administered combined metabolic …
[HTML][HTML] Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis
Introduction The aim of this study was to (1) replicate previous associations between six
blood lipids and Alzheimer's disease (AD)(Proitsi et al 2015) and (2) identify novel …
blood lipids and Alzheimer's disease (AD)(Proitsi et al 2015) and (2) identify novel …