Evaluation of the role of atherogenic index of plasma in the reversion from Prediabetes to normoglycemia or progression to Diabetes: a multi-center retrospective …

H Yang, M Kuang, R Yang, G Xie, G Sheng… - Cardiovascular …, 2024 - Springer
Background Atherosclerosis is closely linked with glucose metabolism. We aimed to
investigate the role of the atherogenic index of plasma (AIP) in the reversal of prediabetes to …

Joint representation learning for retrieval and annotation of genomic interval sets

E Gharavi, NJ LeRoy, G Zheng, A Zhang, DE Brown… - Bioengineering, 2024 - mdpi.com
As available genomic interval data increase in scale, we require fast systems to search
them. A common approach is simple string matching to compare a search term to metadata …

Graph embedding and geometric deep learning relevance to network biology and structural chemistry

P Lecca, M Lecca - Frontiers in Artificial Intelligence, 2023 - frontiersin.org
Graphs are used as a model of complex relationships among data in biological science
since the advent of systems biology in the early 2000. In particular, graph data analysis and …

Methods for constructing and evaluating consensus genomic interval sets

J Rymuza, Y Sun, G Zheng, NJ LeRoy… - Nucleic Acids …, 2024 - academic.oup.com
The amount of genomic region data continues to increase. Integrating across diverse
genomic region sets requires consensus regions, which enable comparing regions across …

[PDF][PDF] Methods for evaluating unsupervised vector representations of genomic regions

G Zheng, J Rymuza, E Gharavi… - NAR Genomics and …, 2024 - academic.oup.com
Abstract Representation learning models have become a mainstay of modern genomics.
These models are trained to yield vector representations, or embeddings, of various …

Fast clustering and cell-type annotation of scATAC data using pre-trained embeddings

NJ LeRoy, JP Smith, G Zheng, J Rymuza… - NAR Genomics and …, 2024 - academic.oup.com
Data from the single-cell assay for transposase-accessible chromatin using sequencing
(scATAC-seq) are now widely available. One major computational challenge is dealing with …

GenomicDistributions: fast analysis of genomic intervals with Bioconductor

K Kupkova, JV Mosquera, JP Smith, M Stolarczyk… - BMC genomics, 2022 - Springer
Background Epigenome analysis relies on defined sets of genomic regions output by widely
used assays such as ChIP-seq and ATAC-seq. Statistical analysis and visualization of …

Relative importance of triglyceride glucose index combined with body mass index in predicting recovery from prediabetic state to normal fasting glucose: a cohort …

H Yang, M Kuang, J Qiu, S He, C Yu, G Sheng… - Lipids in Health and …, 2024 - Springer
Background Prediabetes is a high-risk state for diabetes, and numerous studies have shown
that the body mass index (BMI) and triglyceride-glucose (TyG) index play significant roles in …

NetREm Network Regression Embeddings reveal cell-type transcription factor coordination for gene regulation

S Khullar, X Huang, R Ramesh, J Svaren, D Wang - bioRxiv, 2023 - biorxiv.org
Transcription factor (TF) coordination plays a key role in target gene (TG) regulation via
protein-protein interactions (PPIs) and DNA co-binding to regulatory elements. Single-cell …

[HTML][HTML] Simple and scalable algorithms for cluster-aware precision medicine

AM Buch, C Liston, L Grosenick - Proceedings of machine learning …, 2024 - ncbi.nlm.nih.gov
AI-enabled precision medicine promises a transformational improvement in healthcare
outcomes. However, training on biomedical data presents significant challenges as they are …