We present an update and revision to our 2010 review on the topic of proton-coupled
electron transfer (PCET) reagent thermochemistry. Over the past decade, the data and …

As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

Transition metal hydrides (MH) are ubiquitous intermediates in a wide range of enzymatic
processes and catalytic reactions, playing a central role in H+/H2 interconversion, the …

Many, if not most, redox reactions are coupled to proton transfers. This includes most
common sources of chemical potential energy, from the bioenergetic processes that power …

Coordination-induced bond weakening is a phenomenon wherein ligand X–H bond
homolysis occurs in concert with the energetically favorable oxidation of a coordinating …

An initial review (PCET1) on proton-coupled electron transfer (PCET) by Huynh and Meyer
appeared in Chemical Reviews in 2007.(1) This is a follow-up on the original. It was …

The selective functionalization of strong C− H bonds and the oxidation of water by cheap
and nontoxic metals are some of the key targets of chemical research today. It has been …

At the core of many important energy conversion processes in chemistry and biology are
oxidation-reduction reactions in which both electrons and protons are transferred. An …

Cytochrome P450 enzymes activate oxygen at heme iron centers to oxidize relatively inert
substrate carbon-hydrogen bonds. Cysteine thiolate coordination to iron is posited to …

TAML activators of peroxides are iron (III) complexes. The ligation by four deprotonated
amide nitrogens in macrocyclic motifs is the signature of TAMLs where the macrocyclic …