The SARS-CoV-2 main protease as drug target
The unprecedented pandemic of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is threatening global health. The virus emerged in late 2019 and can cause a …
(SARS-CoV-2) is threatening global health. The virus emerged in late 2019 and can cause a …
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design
R Hilgenfeld - The FEBS journal, 2014 - Wiley Online Library
This review focuses on the important contributions that macromolecular crystallography has
made over the past 12 years to elucidating structures and mechanisms of the essential …
made over the past 12 years to elucidating structures and mechanisms of the essential …
Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures
A Herrmann - Chemical Society Reviews, 2014 - pubs.rsc.org
Reversible covalent bond formation under thermodynamic control adds reactivity to self-
assembled supramolecular systems, and is therefore an ideal tool to assess complexity of …
assembled supramolecular systems, and is therefore an ideal tool to assess complexity of …
Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets
M Mondal, AKH Hirsch - Chemical Society Reviews, 2015 - pubs.rsc.org
Dynamic combinatorial chemistry (DCC) has emerged as a powerful strategy to identify
ligands for biological targets given that it enables the target to direct the synthesis and …
ligands for biological targets given that it enables the target to direct the synthesis and …
Drug target miRNAs: chances and challenges
MF Schmidt - Trends in biotechnology, 2014 - cell.com
miRNAs, short ribonucleic acid gene regulators, are increasingly popular drug targets.
Traditionally 'undruggable'proteins can be targeted via their miRNA gene regulators …
Traditionally 'undruggable'proteins can be targeted via their miRNA gene regulators …
The ways and means of fragment-based drug design
Fragment-based drug design (FBDD) has emerged as a mainstream approach for the rapid
and efficient identification of building blocks that can be used to develop high-affinity ligands …
and efficient identification of building blocks that can be used to develop high-affinity ligands …
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
L Zhu, S George, MF Schmidt, SI Al-Gharabli… - Antiviral research, 2011 - Elsevier
SARS coronavirus main protease (SARS-CoV Mpro) is essential for the replication of the
virus and regarded as a major antiviral drug target. The enzyme is a cysteine protease, with …
virus and regarded as a major antiviral drug target. The enzyme is a cysteine protease, with …
Advances in the synthesis of non-annelated polynuclear heterocyclic systems comprising the 1, 2, 5-oxadiazole ring
LL Fershtat, NN Makhova - Russian Chemical Reviews, 2016 - iopscience.iop.org
This review is concerned with recently developed synthetic methods for non-annelated
polynuclear heterocyclic systems that incorporate, along with a furazan and (or) furoxan ring …
polynuclear heterocyclic systems that incorporate, along with a furazan and (or) furoxan ring …
Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial …
M Mondal, N Radeva, H Fanlo‐Virgós… - Angewandte Chemie …, 2016 - Wiley Online Library
Fragment‐based drug design (FBDD) affords active compounds for biological targets. While
there are numerous reports on FBDD by fragment growing/optimization, fragment linking has …
there are numerous reports on FBDD by fragment growing/optimization, fragment linking has …