Immune receptors are not randomly distributed at the plasma membrane of lymphocytes but
are segregated into specialized domains that function as platforms to initiate signalling, as …

Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are anchored at the outer leaflet
of plasma membranes (PMs) of all eukaryotic organisms studied so far by covalent linkage …

How different classes of the B cell antigen receptor (BCR) sense viral antigens used in
vaccination protocols is poorly understood. Here, we study antigen binding and sensing of …

Subcapsular sinus macrophages (SSMs) play a key role in immune defense by forming
immunological barriers that control the transport of antigens from lymph into lymph node …

The recently determined cryo-EM structures of the T cell antigen receptor (TCR) and B cell
antigen receptor (BCR) show in molecular details the interactions of the ligand-binding part …

Antibodies are exceptionally versatile molecules with remarkable flexibility in their binding
properties. Their natural targets range from small-molecule toxins, across viruses of different …

Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are anchored at the outer leaflet
of the plasma membrane (PM) bilayer by covalent linkage to a typical glycolipid and …

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer
phospholipid layer of eukaryotic plasma membranes exclusively by a glycolipid. GPI-APs …

Morphogenesis requires building stable macromolecular structures from highly dynamic
proteins. Muscles are anchored by long-lasting integrin adhesions to resist contractile force …

Here we intend to shift the “DNA-and information-centric” conception of biological
inheritance, with the accompanying exclusion of any non-DNA matter, to a “poly-matter …