Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …

Accurate positioning of spindles is essential for asymmetric mitotic and meiotic cell divisions
that are crucial for animal development and oocyte maturation, respectively. The …

Dynein at the cortex contributes to microtubule-based positioning processes such as spindle
positioning during embryonic cell division and centrosome positioning during fibroblast …

Orientation of the cell division axis is essential for the correct development and maintenance
of tissue morphology, both for symmetric cell divisions and for the asymmetric distribution of …

Neurons begin their life as simple spheres, but can ultimately assume an elaborate
morphology with numerous, highly arborized dendrites, and long axons. This is achieved via …

The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the
first large-scale serial electron tomography of whole mitotic spindles in early C. elegans …

Positioning of centrosomes is vital for cell division and development. In metazoan cells,
spindle positioning is controlled by a dynamic pool of subcortical actin that organizes in …

Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

Heterozygous LIS1 mutations are responsible for the human neuronal migration disorder
lissencephaly. Mitotic functions of LIS1 have been suggested from many organisms …

Multipolar spindles are very rare in normal tissues, but they are much more prevalent in
many tumors, which might be induced by the mechanical confinements from overcrowding …