The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell
specific growth factor stimulating angiogenesis and vascular permeability. Some family …

The gut microbiota influences intestinal barrier integrity through mechanisms that are
incompletely understood. Here we show that the commensal microbiota weakens the …

Vascular endothelial cells are ordinarily quiescent in adult humans and divide less than
once per decade. When tumors reach a size of about 0.2–2.0 mm in diameter, they become …

NRPs (neuropilins) are co-receptors for class 3 semaphorins, polypeptides with key roles in
axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of …

The semaphorins and their receptors, the neuropilins and the plexins, were originally
characterized as constituents of the complex regulatory system responsible for the guidance …

The epidermal growth factor receptor (EGFR) family comprehends four different tyrosine
kinases (EGFR, ErbB‐2, ErbB‐3, and ErbB‐4) that are activated following binding to …

It is established that tumor cell-derived VEGF acts on endothelial cells to promote
angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse …

The last decade has witnessed the approval of monoclonal antibodies (mAbs) and small
molecule tyrosine kinase inhibitors (TKIs) for targeting of oncogenic signaling pathways …

Vascular endothelial growth factor (VEGF) is associated with tumor angiogenesis and poor
prognosis in human colorectal cancer (CRC). VEGF receptor-1 (VEGFR-1 or Flt-1) is a high …