The pathogenesis of Legionella pneumophila is derived from its growth within lung
macrophages after aerosols are inhaled from contaminated water sources. Interest in this …

The type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative
bacteria as a weapon against eukaryotic hosts or prokaryotic competitors. It assembles into …

A large number of highly pathogenic bacteria utilize secretion systems to translocate effector
proteins into host cells. Using these effectors, the bacteria subvert host cell processes during …

Rab GTPases are frequent targets of vacuole-living bacterial pathogens for appropriate
trafficking of the vacuole. Here we discover that bacterial effectors including VirA from …

Protein N-myristoylation is a 14-carbon fatty-acid modification that is conserved across
eukaryotic species and occurs on nearly 1% of the cellular proteome,. The ability of the …

The identification of virulent proteins in any de-novo sequenced genome is useful in
estimating its pathogenic ability and understanding the mechanism of pathogenesis …

The bacterial pathogen Legionella pneumophila replicates in a specialized vacuole within
host cells. Establishment of the replication vacuole depends on the Dot/Icm translocation …

Bacteria of Shigella spp., the causative agents of shigellosis in humans, possess a
repertoire of∼ 25–30 effectors injected into host cells by a type III secretion apparatus …

Upon entry into host cells, intracellular bacterial pathogens establish a variety of replicative
niches. Although some remodel phagosomes, others rapidly escape into the cytosol of …

Microbial pathogens have coevolved with their hosts, often for millions of years, and in the
process have developed a variety of virulence mechanisms to ensure their survival, typically …