Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
DNA methylation analysis: choosing the right method
S Kurdyukov, M Bullock - Biology, 2016 - mdpi.com
In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …
methylation status of DNA samples. However, choosing the method that is best suited to …
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
Abstract Motivation: The recently released Infinium HumanMethylation450 array (the
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
ChAMP: 450k chip analysis methylation pipeline
TJ Morris, LM Butcher, A Feber, AE Teschendorff… - …, 2014 - academic.oup.com
Abstract The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-
throughput DNA methylation analysis. Several methods for normalization and processing of …
throughput DNA methylation analysis. Several methods for normalization and processing of …
Identification of differentially methylated cell types in epigenome-wide association studies
An outstanding challenge of epigenome-wide association studies (EWASs) performed in
complex tissues is the identification of the specific cell type (s) responsible for the observed …
complex tissues is the identification of the specific cell type (s) responsible for the observed …
[HTML][HTML] Methylome-wide analysis of chronic HIV infection reveals five-year increase in biological age and epigenetic targeting of HLA
HIV-infected individuals are living longer on antiretroviral therapy, but many patients display
signs that in some ways resemble premature aging. To investigate and quantify the impact of …
signs that in some ways resemble premature aging. To investigate and quantify the impact of …
ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip
Abstract The Illumina HumanMethylation450 BeadChip is increasingly utilized in epigenome-
wide association studies, however, this array-based measurement of DNA methylation is …
wide association studies, however, this array-based measurement of DNA methylation is …
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …
epigenetic modifications associated with elevated adiposity, including DNA methylation …
DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan
T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …
their potential in predicting healthspan and application in age-related illnesses, such as …
Distress during pregnancy: epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior
Objective: Increased risk of psychopathology is observed in children exposed to maternal
prenatal distress, and elevated maternal cortisol and epigenetic regulation of placental …
prenatal distress, and elevated maternal cortisol and epigenetic regulation of placental …