Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis

N Celarain, J Tomas-Roig - Frontiers in Genetics, 2019 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system
characterized by loss of coordination, weakness, dysfunctions in bladder capacity, bowel …

T cell-redirected antigen-binding molecule for cells having immunosuppression function

T Igawa, T Ishiguro, S Sakaguchi… - US Patent …, 2022 - Google Patents
5,624,821 A 5,648,260 A 6,025,165 A 6,143,297 A 6,805,869 B2 7,183,076 B2 7,659,384
B2 8,080,250 B1 8,263,073 B2 8,298,801 B2 8,398,956 B2 8,592,562 B2 8,871,912 B2 …

Cytotoxicity-inducing therapeutic agent

J Nezu, A Narita, T Ishiguro, M Sakurai… - US Patent …, 2021 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
55581241&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Cell injury inducing therapeutic drug for use in cancer therapy

Y Kinoshita, Y Kawai, T Tsunenari, T Ishiguro… - US Patent …, 2021 - Google Patents
The present invention provides anticancer agents comprising as an active ingredient a
bispecific antibody that comprises a domain comprising a glypican 3-binding antibody …

Method for enhancing humoral immune response

T Igawa - US Patent 11,649,293, 2023 - Google Patents
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate
hydrogen phosphate dichloride Chemical compound P (= O)(O)(O)[O-].[K+]. P (= O)(O)([O …

Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function

T Tsunenari, Y Matsuda, T Miyazaki… - US Patent …, 2023 - Google Patents
2018-05-24 Assigned to CHUGAI SEIYAKU KABUSHIKI KAISHA reassignment CHUGAI
SEIYAKU KABUSHIKI KAISHA ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

Immunoactivating antigen-binding molecule

T Igawa, T Miyazaki, K Taniguchi… - US Patent 11,485,790, 2022 - Google Patents
It was discovered that the use of an antigen-binding molecule having a cancer-specific
antigen-binding domain, and a TNF superfamily-binding domain or a TNF receptor …

Cytotoxicity-inducing therapeutic agent

J Nezu, T Ishiguro, A Narita, A Sakamoto, Y Kawai… - 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46171913&utm_source= google_patent&utm_medium= platform_link&utm_campaign …