Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …

Coronaviruses remodel the intracellular host membranes during replication, forming double-
membrane vesicles (DMVs) to accommodate viral RNA synthesis and modifications,. SARS …

Chikungunya virus (CHIKV) is a single positive-stranded RNA virus of the Togaviridae family
and Alphavirus genus, with a typical lipid bilayer envelope structure, and is the causative …

Chikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-
severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating …

Chikungunya virus (CHIKV) nonstructural protein 1 (nsP1) contains both the N7-guanine
methyltransferase and guanylyltransferase activities and catalyzes the 5′ end cap …

Chikungunya virus is a re-emerging arbovirus that has caused epidemic outbreaks in recent
decades. Patients in older age groups with high viral load and severe immunologic …

Background: The chikungunya virus (CHIKV), transmitted by infected Aedes mosquitoes,
has caused a significant number of infections worldwide. In Brazil, the emergence of the …

RNA capping is an essential trigger for protein translation in eukaryotic cells. Many viruses
have evolved various strategies for initiating the translation of viral genes and generating …

Chikungunya is a re-emerging viral infection of worldwide concern, and new antiviral
therapeutics are necessary to combat this disease. Inhibitors of the non-structural protein 1 …

West Nile virus (WNV) is the most prevalent mosquito-borne disease and the leading cause
of viral encephalitis in the continental United States. It belongs to the Flavivirus family which …