Exosomes emerged as valuable sources of disease biomarkers and new therapeutic tools.
However, extracellular vesicles isolation with exosome-like characteristics from certain …

Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

L1CAM is a transmembrane protein expressed on neurons that was presumed to be found
on neuron-derived extracellular vesicles (NDEVs) in human biofluids. We developed a …

Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …

When released into biological fluids like blood or saliva, brain extracellular vesicles (EVs)
might provide a window into otherwise inaccessible tissue, contributing useful biomarkers of …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-
motor symptoms and loss of dopaminergic neurons of the substantia nigra. Inflammation and …

Abstract Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are
ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the …

Massively parallel sequencing of the polyadenylated RNAs has played a key role in
delineating transcriptome complexity, including alternative use of an exon, promoter, 5′ or …