Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …

Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity …

Background Co-expression correlations provide the ability to predict gene functionality
within specific biological contexts, such as different tissue and disease conditions. However …

Natural killer (NK) cells have clinical potential against cancer; however, multiple limitations
hinder the success of NK cell therapy. Here, we performed unbiased functional mapping of …

The eQTL Catalogue is an open database of uniformly processed human molecular
quantitative trait loci (QTLs). We are continuously updating the resource to further increase …

Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally
coordinated splicing programs during developmental transitions are poorly understood …

Genome-wide association studies (GWAS) for biomarkers important for clinical phenotypes
can lead to clinically relevant discoveries. Conventional GWAS for quantitative traits are …

Although COVID-19 vaccines have been developed, multiple pathogenic coronavirus
species exist, urging on development of multispecies coronavirus vaccines. Here we …