Microbial defenses against mobile genetic elements and viruses: Who defends whom from what?
Prokaryotes have numerous mobile genetic elements (MGEs) that mediate horizontal gene
transfer (HGT) between cells. These elements can be costly, even deadly, and cells use …
transfer (HGT) between cells. These elements can be costly, even deadly, and cells use …
Ecological and evolutionary solutions to the plasmid paradox
MA Brockhurst, E Harrison - Trends in microbiology, 2022 - cell.com
The'plasmid paradox'arises because, although plasmids are common features of bacterial
genomes, theoretically they should not exist: rates of conjugation were believed insufficient …
genomes, theoretically they should not exist: rates of conjugation were believed insufficient …
Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains
SA Rella, YA Kulikova, ET Dermitzakis… - Scientific Reports, 2021 - nature.com
Vaccines are thought to be the best available solution for controlling the ongoing SARS-CoV-
2 pandemic. However, the emergence of vaccine-resistant strains may come too rapidly for …
2 pandemic. However, the emergence of vaccine-resistant strains may come too rapidly for …
Models of plant resistance deployment
Owing to their evolutionary potential, plant pathogens are able to rapidly adapt to genetically
controlled plant resistance, often resulting in resistance breakdown and major epidemics in …
controlled plant resistance, often resulting in resistance breakdown and major epidemics in …
[HTML][HTML] Bacterial biodiversity drives the evolution of CRISPR-based phage resistance
About half of all bacteria carry genes for CRISPR–Cas adaptive immune systems, which
provide immunological memory by inserting short DNA sequences from phage and other …
provide immunological memory by inserting short DNA sequences from phage and other …
Coevolution between bacterial CRISPR-Cas systems and their bacteriophages
CRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity
against their viruses (bacteriophages and phages) and other parasitic genetic elements …
against their viruses (bacteriophages and phages) and other parasitic genetic elements …
Evolutionary ecology and interplay of prokaryotic innate and adaptive immune systems
Like many organisms, bacteria and archaea have both innate and adaptive immune systems
to defend against infection by viruses and other parasites. Innate immunity most commonly …
to defend against infection by viruses and other parasites. Innate immunity most commonly …
It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements
Articles on CRISPR commonly open with some variant of the phrase “these short
palindromic repeats and their associated endonucleases (Cas) are an adaptive immune …
palindromic repeats and their associated endonucleases (Cas) are an adaptive immune …
Vaccine escape in a heterogeneous population: insights for SARS-CoV-2 from a simple model
As a countermeasure to the SARS-CoV-2 pandemic, there has been swift development and
clinical trial assessment of candidate vaccines, with subsequent deployment as part of mass …
clinical trial assessment of candidate vaccines, with subsequent deployment as part of mass …
Transient eco-evolutionary dynamics early in a phage epidemic have strong and lasting impact on the long-term evolution of bacterial defences
Organisms have evolved a range of constitutive (always active) and inducible (elicited by
parasites) defence mechanisms, but we have limited understanding of what drives the …
parasites) defence mechanisms, but we have limited understanding of what drives the …