Several studies show that a significantly stronger association is obvious between increased
body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are …

The prevalence of obesity has markedly increased over the past two decades, especially in
the industrialized countries. While the impact of excess body weight on the development of …

Adipokines (leptin, adiponectin, and hepatocyte growth factor (HGF)) secreted from adipose
tissue have come to be recognized for their contribution to the mechanisms by which obesity …

The adipocytokines are biologically active polypeptides that are produced either exclusively
or substantially by the adipocytes, and act by endocrine, paracrine, and autocrine …

The Notch signaling plays a key role in cell differentiation, survival, and proliferation through
diverse mechanisms. Notch signaling is also involved in vasculogenesis and angiogenesis …

Experimental, epidemiological and clinical evidence implicates insulin resistance and its
accompanying hyperinsulinaemia in the development of cancer, but the relative importance …

One in eight women will develop breast cancer over their lifetime making it the most
common female cancer. The cause of breast cancer is multifactorial and includes hormonal …

Leptin, a product of adipocytes, is involved in the regulation of body weight and results
strongly correlated to body fat content. An excess of fat mass represents a breast cancer risk …

Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …

Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to
incidence and mortality. In recent years, the negative role of obesity during BC development …