Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Further work on mediators and pathways that are common across different models and
occur in human osteoarthritis and that impact the osteoarthritis disease process at different …

Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

So far, the connections between obesity and skeleton have been extensively explored, but
the results are inconsistent. Obesity is thought to affect bone health through a variety of …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

Important advances in our understanding of the relationships between adipokines,
inflammation and the immune response have been achieved in the past 10 years. White …

Osteoarthritis (OA) is a common chronic joint disorder with a multifactorial etiology including
genetic and environmental factors. Metabolic triggered inflammation, induced by nutrient …

Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Obesity has reached epidemic proportions in the Western society and is increasing in the
developing world. It is considered as one of the major contributors to the global burden of …