Itch is one of the most primal sensations, being both ubiquitous and important for the well-
being of animals. For more than a century, a desire to understand how itch is encoded by the …

Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of
epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and …

Migraine is one of the most prevalent and disabling neurovascular disorders worldwide.
However, despite the increase in awareness and research, the understanding of migraine …

The purinergic receptor P2X ligand-gated ion channel 3 (P2X3) is crucially involved in
peripheral nociceptive processes of somatic and visceral pain. Endometriosis pain is …

We previously showed that gastrin-releasing peptide receptor (GRPR) in the spinal cord is
important for mediating nonhistaminergic itch. Neuromedin B receptor (NMBR), the second …

Pain represents a very large social and clinical problem since the current treatment provides
insufficient pain relief. Plasticity of pain receptors together with sensitisation of sensory …

Background: A recent study by Mishra and Hoon identified B-type natriuretic peptide (BNP)
as an important peptide for itch transmission and proposed that BNP activates spinal …

Chronic itch poses major health care and economic burdens worldwide. In 2013, B‐type
natriuretic peptide (BNP) was identified as an itch‐selective neuropeptide and shown to be …

Peripheral stimuli are transduced by specific receptors expressed by sensory neurons and
are further processed in the dorsal horn of spinal cord before to be transmitted to the brain …

Abstract Purinergic P2X3 receptors (P2X3Rs) play an important role in pain pathologies,
including migraine. In trigeminal neurons, P2X3Rs are constitutively downregulated by …