Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

P Liu, H Jin, Y Chen, D Wang, H Yan, M Wu… - Chinese Chemical …, 2024 - Elsevier
The pharmaceutical industry is now paying increased attention to continuous manufacturing.
While the revolution to continuous and automated manufacturing is deepening in most of the …

Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling

K Pitt, R Peña, JD Tew, K Pal, R Smith, ZK Nagy… - Powder Technology, 2018 - Elsevier
Particle design via spherical agglomeration is a size enlargement technique used in various
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …

Continuous crystallization processes in pharmaceutical manufacturing: A review

J Orehek, D Teslic, B Likozar - Organic Process Research & …, 2020 - ACS Publications
This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Progress to date in the design and operation of continuous crystallization processes for pharmaceutical applications

B Wood, KP Girard, CS Polster… - … Process Research & …, 2019 - ACS Publications
Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …

Recent progress in continuous crystallization of pharmaceutical products: precise preparation and control

Y Ma, S Wu, EGJ Macaringue, T Zhang… - … Process Research & …, 2020 - ACS Publications
Crystallization, as a solid–liquid separation process, is employed to purify and isolate a
great diversity of crystalline pharmaceutical products. In recent years, continuous …

Nucleation and crystal growth in continuous crystallization

J McGinty, N Yazdanpanah, C Price, JH ter Horst… - 2020 - books.rsc.org
Continuous crystallization has been a common process in the fine chemicals and
petrochemical industries for decades. the advantage of continuous crystallization led other …

[HTML][HTML] End-to-end continuous manufacturing of conventional compressed tablets: From flow synthesis to tableting through integrated crystallization and filtration

A Domokos, B Nagy, M Gyürkés, A Farkas… - International journal of …, 2020 - Elsevier
An end-to-end continuous pharmaceutical manufacturing process was developed for the
production of conventional direct compressed tablets on a proof-of-concept level for the first …

Current trends in API co-processing: spherical crystallization and co-precipitation techniques

MR Dhondale, AG Nambiar, M Singh, AR Mali… - Journal of …, 2023 - Elsevier
Abstract Active Pharmaceutical Ingredients (APIs) do not always exhibit processable
physical properties, which makes their processing in an industrial setup very demanding …

Design of the spherical agglomerate size in crystallization by developing a two‐step bridging mechanism and the model

C Yu, M Yao, Y Ma, Y Liu, S Guo, S Xu… - AIChE …, 2022 - Wiley Online Library
Spherical agglomeration technology can produce high‐performance spherical particles in a
single crystallization unit, although it is still challenging to control the particle size and …