Background Cognitive impairment, an increasing mental health issue, is a core feature of the
aging brain and neurodegenerative diseases. Industrialized nations especially, have …

The hypothalamus is a critical brain region for the regulation of energy homeostasis. Over
the years, studies on energy metabolism primarily focused on the neuronal component of …

Molecular neuroimaging studies provide mounting evidence that neuroinflammation plays a
contributory role in the pathogenesis of major depressive disorder (MDD). This has been the …

Obesity is a widespread medical problem, for which many drugs have been developed,
each with its own limitations. Orlistat, a lipase inhibitor, functions as a fat absorption blocker …

Poor nutrition, lack of exercise, and genetic predisposition all contribute to the growing
epidemic of obesity. Overweight/obesity create an environment of chronic inflammation that …

Amino acid substitutions in the kinase domain of the human CSF1R gene are associated
with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and …

Hepatic encephalopathy (HE) is neurological disarray manifested as a sequel to chronic and
acute liver failure (ALF). A potentially fatal consequence of ALF is brain edema with …

Excess dietary sucrose is associated with obesity and metabolic diseases. This relationship
is driven by the malfunction of several cell types and tissues critical for the regulation of …

Abstract Background/Objective As the obesity epidemic continues, the understanding of
macronutrient influence on central nervous system function is critical for understanding diet …

There is accumulating evidence that an obesogenic Western diet causes neuroinflammatory
damage to the brain, which then promotes further appetitive behaviour. Neuroinflammation …