Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

SUMMARY A comprehensive classification system for transmembrane molecular
transporters has been developed and recently approved by the transport panel of the …

Abstract The Transporter Classification Database (TCDB; tcdb. org) is a freely accessible
reference resource, which provides functional, structural, mechanistic, medical and …

Corynebacterium glutamicum has played a principal role in the progress of the amino acid
fermentation industry. The complete genome sequence of the representative wild-type strain …

Previous work defined several families of secondary active transporters, including the
prokaryotic small multidrug resistance (SMR) and rhamnose transporter (RhaT) families as …

Corynebacterium glutamicum possesses both phosphoenolpyruvate carboxylase (PEPCx)
and pyruvate carboxylase (PCx) as anaplerotic enzymes for growth on carbohydrates. To …

Virulence of the opportunistic pathogen Pseudomonas aeruginosa involves the coordinate
expression of a wide range of virulence factors including type IV pili which are required for …

Background Amino acids are the building blocks of proteins. They also provide raw
materials for a variety of important cellular processes such as energy generation, nitrogen …

Transport processes play a pivotal role in cellular metabolism, eg for the uptake of nutrients
or the excretion of metabolic waste products. Moreover, they are also important in …

Protein phylogeny, based on primary amino acid sequence relatedness, reflects the
evolutionary process and therefore provides a guide to structure, mechanism and function …