Idiosyncratic biogenesis of intracellular pathogens-containing vacuoles
B Vaughn, Y Abu Kwaik - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
While most bacterial species taken up by macrophages are degraded through processing of
the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway …
the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway …
Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in …
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that exploits moonlighting
functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host …
functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host …
Exogenous L‐Alanine promotes phagocytosis of multidrug‐resistant bacterial pathogens
Multidrug‐resistant bacteria present a major threat to public health that urgently requires
new drugs or treatment approaches. Here, we conduct integrated proteomic and …
new drugs or treatment approaches. Here, we conduct integrated proteomic and …
Evolution and Adaptation of Legionella pneumophila to Manipulate the Ubiquitination Machinery of Its Amoebae and Mammalian Hosts
CTD Price, Y Abu Kwaik - Biomolecules, 2021 - mdpi.com
The ubiquitin pathway is highly conserved across the eukaryotic domain of life and plays an
essential role in a plethora of cellular processes. It is not surprising that many intracellular …
essential role in a plethora of cellular processes. It is not surprising that many intracellular …
Structural and Biophysical properties of therapeutically important proteins Rv1509 and Rv2231A of Mycobacterium tuberculosis
N Rastogi, S Zarin, A Alam, GV Konduru… - International Journal of …, 2023 - Elsevier
Through comparative analyses using BLASTp and BLASTn of the 25 target sequences, our
research identified two unique post-transcriptional modifiers, Rv1509 and Rv2231A, which …
research identified two unique post-transcriptional modifiers, Rv1509 and Rv2231A, which …
Mycobacterium tuberculosis Methyltransferase Rv1515c Can Suppress Host Defense Mechanisms by Modulating Immune Functions Utilizing a Multipronged …
Mycobacterium tuberculosis (M. tb) gene Rv1515c encodes a conserved hypothetical
protein exclusively present within organisms of MTB complex and absent in non-pathogenic …
protein exclusively present within organisms of MTB complex and absent in non-pathogenic …
Self-Adjuvanting Adenoviral Nanovaccine for Effective T-Cell-Mediated Immunity and Long-Lasting Memory Cell Activation against Tuberculosis
CK Sowndharya, S Mehnath, A Ponbharathi… - ACS Infectious …, 2024 - ACS Publications
An enhanced vaccine is immediately required to swap the more than 100 year-old bacillus
Calmette-Guerin (BCG) vaccine against tuberculosis. Here, trimethyl chitosan-loaded …
Calmette-Guerin (BCG) vaccine against tuberculosis. Here, trimethyl chitosan-loaded …
Expression of a unique M. tuberculosis DNA MTase Rv1509 in M. smegmatis alters the gene expression pattern and enhances virulence
Mycobacterium tuberculosis (M. tb) genome encompasses 4,173 genes, about a quarter of
which remain uncharacterized and hypothetical. Considering the current limitations …
which remain uncharacterized and hypothetical. Considering the current limitations …
[HTML][HTML] BCG's role in strengthening immune responses: Implications for tuberculosis and comorbid diseases
The BCG vaccine represents a significant milestone in the prevention of tuberculosis (TB),
particularly in children. Researchers have been developing recombinant BCG (rBCG) …
particularly in children. Researchers have been developing recombinant BCG (rBCG) …
Mycobacterium tuberculosis Rv2387 Facilitates Mycobacterial Survival by Silencing TLR2/p38/JNK Signaling
W Li, W Deng, N Zhang, H Peng, Y Xu - Pathogens, 2022 - mdpi.com
Mycobacterium tuberculosis (Mtb) can evade antimicrobial immunity and persist within
macrophages by interfering with multiple host cellular functions through its virulence factors …
macrophages by interfering with multiple host cellular functions through its virulence factors …