Antileishmanial drug discovery and development: time to reset the model?
AI Olias-Molero, C de la Fuente, M Cuquerella… - Microorganisms, 2021 - mdpi.com
Leishmaniasis is a vector-borne parasitic disease caused by Leishmania species. The
disease affects humans and animals, particularly dogs, provoking cutaneous …
disease affects humans and animals, particularly dogs, provoking cutaneous …
Current leishmaniasis drug discovery
AC Pinheiro, MVN de Souza - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition,
poor health services and unavailability of prophylactic control measures, neglected …
poor health services and unavailability of prophylactic control measures, neglected …
Molecular-level strategic goals and repressors in Leishmaniasis–Integrated data to accelerate target-based heterocyclic scaffolds
M Abirami, BK Kumar, S Dey, S Johri… - European Journal of …, 2023 - Elsevier
Leishmaniasis is a complex of neglected tropical diseases caused by various species of
leishmanial parasites that primarily affect the world's poorest people. A limited number of …
leishmanial parasites that primarily affect the world's poorest people. A limited number of …
Impedimetric immunosensor for rapid and simultaneous detection of Chagas and visceral leishmaniasis for point of care diagnosis
TAR Cordeiro, HR Martins, DL Franco… - Biosensors and …, 2020 - Elsevier
In this work, a dual detection system based on an impedimetric immunosensor was
developed for the first time for the simultaneous detection of anti-Trypanosoma cruzi and anti …
developed for the first time for the simultaneous detection of anti-Trypanosoma cruzi and anti …
Screening marine natural products for new drug leads against trypanosomatids and malaria
M Álvarez-Bardón, Y Pérez-Pertejo, C Ordóñez… - Marine Drugs, 2020 - mdpi.com
Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or developing countries. Almost one-sixth of the world population is at …
those living in poor or developing countries. Almost one-sixth of the world population is at …
Miltefosine and Nifuratel Combination: A Promising Therapy for the Treatment of Leishmania donovani Visceral Leishmaniasis
E Melcon-Fernandez, G Galli, C García-Estrada… - International Journal of …, 2023 - mdpi.com
Visceral leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania
donovani and Leishmania infantum that is endemic not only in East African countries, but …
donovani and Leishmania infantum that is endemic not only in East African countries, but …
Recent advances in chemotherapeutics for leishmaniasis: Importance of the cellular biochemistry of the parasite and its molecular interaction with the host
Leishmaniasis, a category 1 neglected protozoan disease caused by a kinetoplastid
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …
Comparative efficacy of amphotericin B-loaded chitosan nanoparticles and free amphotericin B drug against Leishmania tropica
Background The preparation of an effective drug delivery formulation is an urgent need to
treat cutaneous leishmaniasis (CL). Pentavalent antimonials and Amphotericin B (AmB) are …
treat cutaneous leishmaniasis (CL). Pentavalent antimonials and Amphotericin B (AmB) are …
The management of Babesia, amoeba and other zoonotic diseases provoked by protozoa
C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2023 - Taylor & Francis
Introduction There are 12 protozoan genera that provoke zoonotic disease in humans and
animals. We discuss the most common ones with a highlight on Babesia spp and …
animals. We discuss the most common ones with a highlight on Babesia spp and …
In vitro identification of imidazo [1, 2-a] pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition
MA Bazin, S Cojean, F Pagniez, G Bernadat… - European Journal of …, 2021 - Elsevier
Leishmaniasis constitutes a severe public health problem, with an estimated prevalence of
12 million cases. This potentially fatal disease has a worldwide distribution and in 2012, the …
12 million cases. This potentially fatal disease has a worldwide distribution and in 2012, the …