Antileishmanial drug discovery and development: time to reset the model?

AI Olias-Molero, C de la Fuente, M Cuquerella… - Microorganisms, 2021 - mdpi.com
Leishmaniasis is a vector-borne parasitic disease caused by Leishmania species. The
disease affects humans and animals, particularly dogs, provoking cutaneous …

Current leishmaniasis drug discovery

AC Pinheiro, MVN de Souza - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition,
poor health services and unavailability of prophylactic control measures, neglected …

Molecular-level strategic goals and repressors in Leishmaniasis–Integrated data to accelerate target-based heterocyclic scaffolds

M Abirami, BK Kumar, S Dey, S Johri… - European Journal of …, 2023 - Elsevier
Leishmaniasis is a complex of neglected tropical diseases caused by various species of
leishmanial parasites that primarily affect the world's poorest people. A limited number of …

Impedimetric immunosensor for rapid and simultaneous detection of Chagas and visceral leishmaniasis for point of care diagnosis

TAR Cordeiro, HR Martins, DL Franco… - Biosensors and …, 2020 - Elsevier
In this work, a dual detection system based on an impedimetric immunosensor was
developed for the first time for the simultaneous detection of anti-Trypanosoma cruzi and anti …

Screening marine natural products for new drug leads against trypanosomatids and malaria

M Álvarez-Bardón, Y Pérez-Pertejo, C Ordóñez… - Marine Drugs, 2020 - mdpi.com
Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or developing countries. Almost one-sixth of the world population is at …

Miltefosine and Nifuratel Combination: A Promising Therapy for the Treatment of Leishmania donovani Visceral Leishmaniasis

E Melcon-Fernandez, G Galli, C García-Estrada… - International Journal of …, 2023 - mdpi.com
Visceral leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania
donovani and Leishmania infantum that is endemic not only in East African countries, but …

Recent advances in chemotherapeutics for leishmaniasis: Importance of the cellular biochemistry of the parasite and its molecular interaction with the host

R Singh, M Kashif, P Srivastava, PP Manna - Pathogens, 2023 - mdpi.com
Leishmaniasis, a category 1 neglected protozoan disease caused by a kinetoplastid
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …

Comparative efficacy of amphotericin B-loaded chitosan nanoparticles and free amphotericin B drug against Leishmania tropica

A Sohail, RU Khan, M Khan, M Khokhar, S Ullah… - Bulletin of the National …, 2021 - Springer
Background The preparation of an effective drug delivery formulation is an urgent need to
treat cutaneous leishmaniasis (CL). Pentavalent antimonials and Amphotericin B (AmB) are …

The management of Babesia, amoeba and other zoonotic diseases provoked by protozoa

C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2023 - Taylor & Francis
Introduction There are 12 protozoan genera that provoke zoonotic disease in humans and
animals. We discuss the most common ones with a highlight on Babesia spp and …

In vitro identification of imidazo [1, 2-a] pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition

MA Bazin, S Cojean, F Pagniez, G Bernadat… - European Journal of …, 2021 - Elsevier
Leishmaniasis constitutes a severe public health problem, with an estimated prevalence of
12 million cases. This potentially fatal disease has a worldwide distribution and in 2012, the …