Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues
by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do …

Adult stem cells, particularly those resident in tissues with little turnover, are largely
quiescent and only activate in response to regenerative demands, while embryonic stem …

Highlights•Multiple PTMs can coordinately determine a functional outcome.•Functional
consequences depend on the effects, number, positioning and type of PTMs.•PTM interplay …

RNA modifications represent a novel layer of regulation of gene expression. Functional
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …

Metazoan development from a one-cell zygote to a fully formed organism requires complex
cellular differentiation and communication pathways. To coordinate these processes …

The response to systemic infection and injury requires the rapid adaptation of hematopoietic
stem cells (HSCs), which proliferate and divert their differentiation toward the myeloid …

Reversible modification of proteins with linkage-specific ubiquitin chains is critical for
intracellular signaling. Information on physiological roles and underlying mechanisms of …

Rapidity and specificity are characteristic features of proteolysis mediated by the ubiquitin-
proteasome system. Therefore, the UPS is ideally suited for the remodeling of the embryonic …

An integrative understanding of nuclear events including transcription in normal and cancer
cells requires comprehensive and quantitative measurement of protein dynamics that …

Stem cells preserve tissue homeostasis by replacing the cells lost through damage or
natural turnover. Thus, stem cells and their daughters can adopt two identities, characterized …