The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

The concept that adenine and uridine nucleotides function as extracellular signaling
molecules has been markedly expanded in the last decade. At least 15 nucleotide-activated …

Extracellular ATP and other nucleotides function as autocrine and paracrine signaling
factors in many tissues. Recent studies suggest that P2 nucleotide receptors and ecto …

The involvement of P2Y receptors, which are activated by extracellular nucleotides, in
proliferative regulation of human lung epithelial cells is unclear. Here we show that …

Given the widespread importance of purinergic receptor-evoked signaling, understanding
how ATP and other nucleotides are released from cells in a regulated manner is an …

Anticancer drug resistance is a significant impediment in current cancer treatment.
Extracellular vesicles (EVs) derived from cancer cells were recently acknowledged as a …

There are nineteen different receptor proteins for adenosine, adenine and uridine
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled …