The phylum Apicomplexa comprises important eukaryotic parasites that invade host tissues
and cells using a unique mechanism of gliding motility. Gliding is powered by actomyosin …

To best understand parasite, host, and vector morphologies, host–parasite interactions, and
to develop new drug and vaccine targets, structural data should, ideally, be obtained and …

Apicomplexan parasites secrete contents of the rhoptries, club-shaped organelles in the
apical region, into host cells to permit their invasion and establishment of infection. The …

In Apicomplexa, rhoptry discharge is essential for invasion and involves an apical vesicle
(AV) docking one or two rhoptries to a macromolecular secretory apparatus. Toxoplasma …

In Toxoplasma gondii, the conoid comprises a cone with spiraling tubulin fibers, preconoidal
rings, and intraconoidal microtubules. This dynamic organelle undergoes extension and …

Structural biology is a field of research that investigates the structure and organization of
macromolecules to decipher their functional mechanisms. Traditionally, it has adopted a …

Rhoptries are specialized secretory organelles conserved across the Apicomplexa phylum,
essential for host cell invasion and critical for subverting of host cellular and immune …

Bacterial surface nanomachines are often refractory to structural determination in their intact
form due to their extensive association with the cell envelope preventing them from being …

Malaria remains a major public health problem around the world, with an estimated death
toll of 619 000 in 2021. Malaria is caused by the Apicomplexa parasite Plasmodium, which …

The following chapter summarizes the current research on SARS-CoV-2, with particular
interest on its binding to cellular receptors and its impact on coagulation disorders. This …