The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

Abstract IL-12 and IL-23 are closely related cytokines with important roles in the regulation of
tissue inflammation. Converging evidence from studies in mice, human observational …

Interferon-γ (IFNγ) is a pleiotropic cytokine with multiple effects on the inflammatory
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with rising incidence.
Diseased tissues are heavily vascularized. Surprisingly, the pathogenic impact of the …

The connection between inflammation and tumorigenesis is well-established and in the last
decade has received a great deal of supporting evidence from genetic, pharmacological …

Vitiligo is an autoimmune disease of the skin that results in disfiguring white spots. There are
no US Food and Drug Administration–approved treatments for vitiligo, and most off-label …

Cytokines are small proteins that are secreted by a vast majority of cell types in the gut. They
not only establish cell-to-cell interactions and facilitate cellular signaling, but also regulate …

Crohn's disease and ulcerative colitis are two idiopathic inflammatory bowel disorders. In
this paper we discuss the current diagnostic approach, their pathology, natural course, and …