Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

Overcoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In
this respect, Schiff base-related compounds (bearing a R 1 R 2 Cdouble bondNR 3 bond) …

Aloperine (ALO) is a novel type of alkaloid drug that is extracted from S. alopecuroide, and
exert an anti-inflammatory, anti-allergenic, antitumor and antiviral effects. In our study, we …

Cancer cells are more vulnerable to abnormal redox fluctuations due to their imbalanced
antioxidant system, where cell surface receptors sense stress and trigger intracellular signal …

Background: Intracellular copper homeostasis requires a complex system. It has shown
considerable prospects for intervening in the tumor microenvironment (TME) by regulating …

The serine/arginine protein kinases respond to the EGFR-PI3K-AKT signaling module in the
context of pre-mRNA alternative splicing regulation. These enzymes (notably SRPK1 and …

Trace elements are very important substances with low content in the human body. If the
content of some trace elements changes, they are also related to diseases. Acute …

Cuproptosis provides a new therapeutic strategy for cancer treatment and is thought to have
broad clinical application prospects. Nevertheless, some oncological clinical trials have yet …

Chidamide (CDM), a novel histone deacetylase inhibitor, is currently used for patients with
peripheral T-cell lymphoma. Aspirin (ASA), an anti-inflammatory drug, has been shown to …

Background/Aim: Metal-containing compounds (eg, platinum complexes) belong to the
standard armamentarium of cancer chemotherapy. Copper N-(2-hydroxy acetophenone) …