Mitotic cell divisions increase cell number while faithfully distributing the replicated genome
at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell …

Microtubule ends serve as sites of tubulin addition and removal, and at the same time play
crucial roles in microtubule capture, stabilization and attachment to different cellular …

The first mitosis of the mammalian embryo must partition the parental genomes contained in
two pronuclei. In rodent zygotes, sperm centrosomes are degraded, and instead, acentriolar …

The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the
first large-scale serial electron tomography of whole mitotic spindles in early C. elegans …

Successive cell divisions during embryonic cleavage create increasingly smaller cells, so
intracellular structures must adapt accordingly. Mitotic spindle size correlates with cell size …

Gametogenesis in animal oocytes reduces the diploid genome content of germline
precursors to a haploid state in gametes by discarding ¾ of the duplicated chromosomes …

Cells that divide during embryo development require precisely two centrioles during
interphase and four centrioles during mitosis. This precise number is maintained by allowing …

In sexually reproducing animals, oocytes arrest at diplotene or diakinesis and resume
meiosis (meiotic maturation) in response to hormones. Chromosome segregation errors in …

Due to their elongated and polarized morphology, neurons rely on the microtubule (MT)
cytoskeleton for their shape, as well as for efficient intracellular transport that maintains …

During oocyte meiotic cell division in many animals, bipolar spindles assemble in the
absence of centrosomes, but the mechanisms that restrict pole assembly to a bipolar state …