Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

Seven-transmembrane receptors (7TMRs), the most common molecular targets of modern
drug therapy, are critically regulated by β-arrestins, which both inhibit classic G-protein …

Mechanistic and structural studies of membrane proteins require their stabilization in specific
conformations. Single domain antibodies are potent reagents for this purpose, but their …

CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor
(GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes …

The WHIM syndrome is a rare immunodeficiency disorder characterized by warts,
hypogammaglobulinemia, infections, and myelokathexis. Dominant heterozygous mutations …

It is unclear how immune cells traffic between the lymphoid compartment and the central
nervous system (CNS), which lacks lymphatic vessels and is shielded by the blood–brain …

An effective inflammatory immune response first requires the recruitment of cells to the site of
inflammation and then their appropriate activation and regulation. Chemokines are critical in …

Ligand-selective receptor conformations introduce the concept of 'texture'to drug effects, with
respect to ligands possessing quality in addition to quantity of efficacy. This cell-dependent …

Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions,
and dysregulated CKR signaling underpins numerous disease processes of the immune …

The physiological roles of chemokine receptors have expanded beyond host defense and
now represent important targets for intervention in several disease indications. Chemokine …